Histone demethylase PHF8 promotes progression and metastasis of gastric cancer.

ABSTRACT: Histone demethylase plant homeodomain (PHD) finger protein 8 (PHF8) has been implicated in tumor development and malignant progression in various types of cancers. However, its potential roles in gastric cancer (GC) have not been explored. In this report, we show that PHF8 expression is upregulated in GC tissues, and the enhanced PHF8 level indicates a poor prognosis of GC patients. PHF8 knockdown reduces proliferation and metastasis of GC cells, while PHF8 overexpression has the opposite effects. Mechanistically, PHF8 interacts with β-catenin, and binds to the promoter region of vimentin, leading to the promotion of vimentin transcription. In addition, we show that H. pylori, the single most important risk factor for GC, markedly induce PHF8 expression. Our results suggest that

SUBMITTER: Li S 

PROVIDER: S-EPMC5385635 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature