BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.

ABSTRACT:

Objective

Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.

Design

We determined BVES promoter methylation status using an Infinium HumanMethylation450 array screen of patients with UC with and without CAC. We also measured BVES mRNA levels in a tissue microarray consisting of normal colons and CAC samples. Bves^-/- and wild-type mice (controls) were administered azoxymethane (AOM) and dextran sodium sulfate (DSS) t

SUBMITTER: Parang B 

PROVIDER: S-EPMC5385850 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature