Menthol Smokers: Metabolomic Profiling and Smoking Behavior.

ABSTRACT:

Background

The use of menthol in cigarettes and marketing is under consideration for regulation by the FDA. However, the effects of menthol on smoking behavior and carcinogen exposure have been inconclusive. We previously reported metabolomic profiling for cigarette smokers, and novelly identified a menthol-glucuronide (MG) as the most significant metabolite directly related to smoking. Here, MG is studied in relation to smoking behavior and metabolomic profiles.

Methods

This is a cross-sectional study of 105 smokers who smoked two cigarettes in the laboratory one hour apart. Blood nicotine, MG, and exhaled carbon monoxide (CO) boosts were determined (the difference before and after smoking). Spearman correlation, χ², and ANCOVA adjusted for gender, race, and coti

SUBMITTER: Hsu PC 

PROVIDER: S-EPMC5386404 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature