Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children.

ABSTRACT: Several genome-wide association studies have been conducted to investigate the influence of genetic polymorphisms in the development of allergic diseases, but few of them have included the X chromosome. The aim of present study was to perform an X chromosome-wide association study (X-WAS) for asthma symptoms. The study included 1307 children of which 294 were asthma cases. DNA was genotyped using 2.5 HumanOmni Beadchip from Illumina. Statistical analyses were performed in PLINK 1.9, MACH 1.0 and Minimac2. The variant rs12007907 (g.29483892C>A) in IL1RAPL gene was suggestively associated with asthma symptoms in discovery set (odds ratio (OR)=0.49, 95% confidence interval (CI): 0.37-0.67; P=3.33 × 10^-6). This result was replicated in the ProAr cohort in men only (OR=0.4

SUBMITTER: Marques CR 

PROVIDER: S-EPMC5386417 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature