Cued memory decline in biomarker-defined preclinical Alzheimer disease.

ABSTRACT:

Objective

To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging.

Methods

Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ^+/- status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education.

Results

A total of 276 older adults (Clinical Dementia Rating = 0, mean Mini-Mental State Examination score = 29 ± 1.06) were followed up for

SUBMITTER: Papp KV 

PROVIDER: S-EPMC5386436 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature