Overlapping features of polymyositis and inclusion body myositis in HIV-infected patients.

ABSTRACT:

Objective

To characterize patients with myositis with HIV infection.

Methods

All HIV-positive patients with myositis seen at the Johns Hopkins Myositis Center from 2003 to 2013 were included in this case series. Muscle biopsy features, weakness pattern, serum creatine kinase (CK) level, and anti-nucleotidase 1A (NT5C1A) status of HIV-positive patients with myositis were assessed.

Results

Eleven of 1,562 (0.7%) patients with myositis were HIV-positive. Myositis was the presenting feature of HIV infection in 3 patients. Eight of 11 patients had weakness onset at age 45 years or less. The mean time from the onset of weakness to the diagnosis of myositis was 3.6 years (SD 3.2 years). The mean of the highest measured CK levels was 2,796 IU/L (SD 1,592 IU/L). On muscle biop

SUBMITTER: Lloyd TE 

PROVIDER: S-EPMC5386438 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature