Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells.

ABSTRACT: The Warburg effect is an important characteristic of tumor cells, making it an attractive therapeutic target. Current anticancer drug development strategies predominantly focus on inhibitors of the specific molecular effectors involved in tumor cell proliferation. These drugs or natural compounds, many of which target the Warburg effect and the underlying mechanisms, still need to be characterized. To elucidate the anticancer effects of a natural diterpenoid, oridonin, we first demonstrated the anticancer activity of oridonin both in vitro and in vivo in colorectal cancer (CRC) cells. Then miRNA profiling of SW480 cells revealed those intracellular signaling related to energy supply was affected by oridonin, suggesting that glucose metabolism is a potential target for CRC therapy. Moreover

SUBMITTER: Yao Z 

PROVIDER: S-EPMC5386482 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature