Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytes.

ABSTRACT: The female reproductive lifespan is largely determined by the size of primordial follicle pool, which is established following germ cell cyst breakdown around birth. Almost two-third of oocytes are lost during germ cell cysts breakdown, following autophagic and apoptosis mechanisms. To investigate a possible relationship between germ cell cyst breakdown and nutrition supply, we established a starvation model in mouse pups at birth and evaluated the dynamics of cyst breakdown during nutrient deprivation. Our results showed that after 36 h of starvation between 1.5 and 3 d.p.p., indicators of metabolism both at systemic and ovarian level were significantly altered and the germ cell cyst breakdown markedly decreased. We also found that markers of oxidative stress, autophagy and apoptosis were

SUBMITTER: Wang YY 

PROVIDER: S-EPMC5386484 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature