The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4⁺ T-cell-mediated antitumor memory immune response.

ABSTRACT: Tumor metastasis is a major concern in tumor therapy. In our previous studies, a novel tumor therapeutic modality of the cryo-thermal therapy has been presented, highlighting its effect on the suppression of distal metastasis and leading to long-term survival in 4T1 murine mammary carcinoma model. To demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced, in this study, spontaneous metastatic murine B16F10 melanoma model was used. The cryo-thermal therapy induced regression of implanted melanoma and prolonged long-term survival while inhibiting lung metastasis. It also promoted the activation of CD4⁺ CD25^- conventional T cells, while reduced the percentage of CD4⁺ CD25^+<

SUBMITTER: He K 

PROVIDER: S-EPMC5386530 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature