Regulation of RhoA activity by the cellular prion protein.

ABSTRACT: The cellular prion protein (PrP^C) is a highly conserved glycosylphosphatidylinositol (GPI)-anchored membrane protein that is involved in the signal transduction during the initial phase of neurite outgrowth. The Ras homolog gene family member A (RhoA) is a small GTPase that is known to have an essential role in regulating the development, differentiation, survival, and death of neurons in the central nervous system. Although recent studies have shown the dysregulation of RhoA in a variety of neurodegenerative diseases, the role of RhoA in prion pathogenesis remains unclear. Here, we investigated the regulation of RhoA-mediated signaling by PrP^C using both in vitro and in vivo models and found that overexpression of PrP^C significantly induced RhoA inactivati

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC5386549 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature