The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury.

ABSTRACT: The mammalian target of rapamycin (mTOR) signal controls innate and adaptive immune response in multiple immunoregulatory contexts. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells of potent immunosuppressive capacity. In this study, we aimed to investigate the role of MDSCs in the protection of acute kidney injury (AKI) and the regulation of mTOR signal on MDSC's protective role in this context. In mice AKI model, rapamycin administration was associated with improved renal function, restored histological damage and decreased CD4⁺ and CD8⁺ T-cell infiltration in kidney tissue. MDSCs, especially CD11b⁺Ly6G⁺Ly6C^low G-MDSCs were recruited to the injured kidney following the interaction of CXCL1, CXC

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5386577 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature