BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse.

ABSTRACT: The BRE (brain and reproductive expression) gene, highly expressed in nervous and reproductive system organs, plays an important role in modulating DNA damage repair under stress response and pathological conditions. Folliculogenesis, a process that ovarian follicle develops into maturation, is closely associated with the interaction between somatic granulosa cell and oocyte. However, the regulatory role of BRE in follicular development remains undetermined. In this context, we found that BRE is normally expressed in the oocytes and granulosa cells from the primordial follicle stage. There was a reduction in follicles number of BRE mutant (BRE^-/-) mice. It was attributed to increase the follicular atresia in ovaries, as a result of retarded follicular development. We established

SUBMITTER: Yeung CK 

PROVIDER: S-EPMC5386581 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature