IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis.

ABSTRACT: Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10⁺Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-β. Compared with peripheral CD4⁺ T cells, endometrial CD4⁺ T cells highly expressed IL-27 receptors, especially the ectopic endometrium. Under external (2,3,7,8-tet

SUBMITTER: Chang KK 

PROVIDER: S-EPMC5386585 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature