Olanzapine for chemotherapy-induced nausea and vomiting: systematic review and meta-analysis.

ABSTRACT:

Background

Chemotherapy induced nausea and vomiting (CINV) remains the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC).

Objective

Therefore, this meta-analysis was conducted to evaluate the efficacy of olanzapine containing regimen in preventing acute, delayed and overall phases of CINV.

Methods

PubMed, EBSCO, and Cochrane central register of controlled trials electronic databases were searched to identify RCTs that compared the effects of olanzapine with non-olanzapine regimen in preventing CINV. Randomized clinical trials (RCTs) that compared olanzapine containing regimen with non-olanzapine regimen were included. The primary outcomes were the percentage of patients achieving no vomiting o

SUBMITTER: Chelkeba L 

PROVIDER: S-EPMC5386623 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature