A plasma metabolomic signature discloses human breast cancer.

ABSTRACT:

Purpose

Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast cancer irrespective of the cancer subtype.

Methods

Plasma samples were analyzed from healthy women (n = 20) and patients with breast cancer after diagnosis (n = 91) using a liquid chromatography-mass spectrometry platform. Multivariate statistics and a Random Forest (RF) classifier were used to create a metabolomics panel for the diagnosis of human breast cancer.

Results

Metabolomics correctly distinguished between breast cancer patients and healthy control subjects. In the RF supervised class prediction analysis comparing breast cancer and healthy cont

SUBMITTER: Jove M 

PROVIDER: S-EPMC5386702 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature