Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.

ABSTRACT: Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division. The final fates of microtubule-inhibited cells are however often heterogeneous and difficult to predict. While recent work has provided insight into the cell response to inhibitors of microtubule dynamics (taxanes), the cell response to tubulin polymerization inhibitors remains less well characterized. Arylthioindoles (ATIs) are recently developed tubulin inhibitors. We previously identified ATI members that effectively inhibit tubulin polymerization in vitro and cancer cell growth in bulk cell viability assays. Here we characterise in depth the response of cancer cell lines to five selected ATIs. We find that

SUBMITTER: Di Cesare E 

PROVIDER: S-EPMC5386718 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature