Platelet distribution width correlates with prognosis of gastric cancer.

ABSTRACT:

Background

Activated platelets promote tumor cell growth, aberrant angiogenesis, and invasion. However, the value of platelet indices for predicting survival in gastric cancer remains unknown. The goal of this study was to investigate the predictive significance of platelet indices in gastric cancer.

Result

Reduced platelet distribution width (PDW) was significantly correlated with age, carcinoembryonic antigen, tumor stage, nodule stage, and tumor-nodule-metastases stage. Moreover, decreased PDW correlated with a shorter overall survival in gastric cancer. Multivariate analysis identified PDW as an independent prognostic factor for overall survival (hazard ratio: 0.493, 95% confidence interval: 0.319-0.761, p = 0.001).

Method

A total of 294 patients with gastric canc

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5386756 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature