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Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.

ABSTRACT: Despite the advent of many therapeutic agents, such as bortezomib and lenalidomide that have significantly improved the overall survival, multiple myeloma remains an incurable disease. Failure to cure is multifactorial and can be attributed to the underlying genetic heterogeneity of the cancer and to the surrounding micro-environment. Understanding the mutual interaction between myeloma cells and micro-environment may lead to the development of novel treatment strategies able to eradicate this disease. In this review we discuss the principal molecules involved in the micro-environment network in multiple myeloma and the currently available therapies targeting them.

SUBMITTER: Mondello P

PROVIDER: S-EPMC5386771 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.

Mondello Patrizia P Cuzzocrea Salvatore S Navarra Michele M Mian Michael M

Oncotarget 20170301 12

Despite the advent of many therapeutic agents, such as bortezomib and lenalidomide that have significantly improved the overall survival, multiple myeloma remains an incurable disease. Failure to cure is multifactorial and can be attributed to the underlying genetic heterogeneity of the cancer and to the surrounding micro-environment. Understanding the mutual interaction between myeloma cells and micro-environment may lead to the development of novel treatment strategies able to eradicate this d ...[more]

PMID: 28099912

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