Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating.

ABSTRACT:

Background

Eating disorders are lethal and heritable; however, the underlying genetic factors are unknown. Binge eating is a highly heritable trait associated with eating disorders that is comorbid with mood and substance use disorders. Therefore, understanding its genetic basis will inform therapeutic development that could improve several comorbid neuropsychiatric conditions.

Methods

We assessed binge eating in closely related C57BL/6 mouse substrains and in an F₂ cross to identify quantitative trait loci associated with binge eating. We used gene targeting to validate candidate genetic factors. Finally, we used transcriptome analysis of the striatum via messenger RNA sequencing to identify the premorbid transcriptome and the binge-induced transcriptome to infor

SUBMITTER: Kirkpatrick SL 

PROVIDER: S-EPMC5386810 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature