The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.

ABSTRACT: Protein phosphorylation is the most frequent eukaryotic post-translational modification and can act as either a molecular switch or rheostat for protein functions. The deliberate manipulation of protein phosphorylation has great potential for regulating specific protein functions with surgical precision, rather than the gross effects gained by the over/underexpression or complete deletion of a protein-encoding gene. In order to assess the impact of phosphorylation on central metabolism, and thus its potential for biotechnological and medical exploitation, a compendium of highly confident protein phosphorylation sites (p-sites) for the model organism Saccharomyces cerevisiae has been analyzed together with two more datasets from the fungal pathogen Candida albicans Our analysi

SUBMITTER: Vlastaridis P 

PROVIDER: S-EPMC5386872 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature