Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.

ABSTRACT: Maternal exposure to environmental pollutants could affect fetal brain development and increase autism spectrum disorder (ASD) risk in conjunction with differential genetic susceptibility. Organohalogen congeners measured in maternal midpregnancy blood samples have recently shown significant, but negative associations with offspring ASD outcome. We report the first large-scale maternal and fetal genetic study of the midpregnancy serum levels of a set of 21 organohalogens in a subset of 790 genotyped women and 764 children collected in California by the Early Markers for Autism (EMA) Project. Levels of PCB (polychlorinated biphenyl) and PBDE (polybrominated diphenyl ether) congeners showed high maternal and fetal estimated SNP-based heritability (h²_g ) ac

SUBMITTER: Traglia M 

PROVIDER: S-EPMC5386877 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature