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Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.

ABSTRACT: The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations.

SUBMITTER: Kato T 

PROVIDER: S-EPMC538706 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature

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Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.

Kato Takanobu T   Date Tomoko T   Miyamoto Michiko M   Zhao Zijiang Z   Mizokami Masashi M   Wakita Takaji T  

Journal of virology 20050101 1

The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations. ...[more]

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