Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.

ABSTRACT: Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and the associated symptoms of withdrawal. These adaptations have been shown to persist for relatively long periods of time and are believed to be of central importance in promoting the addictive state. In Drosophila, a single exposure to alcohol results in long-lasting alcohol tolerance and symptoms of withdrawal following alcohol clearance. These persistent adaptations involve mechanisms such as long-lasting changes in gene expression and perhaps epigenetic restructuring of chromosomal regions. Histone modifications have emerged as important modulators of gene expression and are thought to orchestrate and maintain the expression of multi-gene networks. Previously genes that contribute to toleran

SUBMITTER: Ghezzi A 

PROVIDER: S-EPMC5387060 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature