Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation.

ABSTRACT:

Background

Acute kidney injury (AKI) occurs frequently after liver transplantation and is associated with the development of chronic kidney disease and increased mortality. There is a lack of data on renal blood flow (RBF), oxygen consumption, glomerular filtration rate (GFR) and renal oxygenation, i.e. the renal oxygen supply/demand relationship, early after liver transplantation. Increased insight into the renal pathophysiology after liver transplantation is needed to improve the prevention and treatment of postoperative AKI. We have therefore studied renal hemodynamics, function and oxygenation early after liver transplantation in humans.

Methods

Systemic hemodynamic and renal variables were measured during two 30-min periods in liver transplant recipients (n = 12) and po

SUBMITTER: Skytte Larsson J 

PROVIDER: S-EPMC5387193 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature