Multi-scale structural community organisation of the human genome.

ABSTRACT:

Background

Structural interaction frequency matrices between all genome loci are now experimentally achievable thanks to high-throughput chromosome conformation capture technologies. This ensues a new methodological challenge for computational biology which consists in objectively extracting from these data the structural motifs characteristic of genome organisation.

Results

We deployed the fast multi-scale community mining algorithm based on spectral graph wavelets to characterise the networks of intra-chromosomal interactions in human cell lines. We observed that there exist structural domains of all sizes up to chromosome length and demonstrated that the set of structural communities forms a hierarchy of chromosome segments. Hence, at all scales, chromosome folding predom

SUBMITTER: Boulos RE 

PROVIDER: S-EPMC5387268 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature