Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans.

ABSTRACT:

Objectives

To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthritis (JIA) using an observational registry.

Methods

Untreated systemic JIA patients enrolled in the CARRA Registry were begun on one of 4 CTPs chosen by the treating physician and patient/family (glucocorticoid [GC] alone; methotrexate [MTX] ± GC; IL1 inhibitor [IL1i] ± GC; IL6 inhibitor [IL6i] ± GC). The primary outcome of clinical inactive disease (CID) without current GC use was assessed at 9 months.

Trial registration

clinicaltrials.gov NCT01697254; first registered 9/28/12 (retrospectively enrolled).

Results

Thirty patients were enrolled at

SUBMITTER: Kimura Y 

PROVIDER: S-EPMC5387287 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature