Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity.

ABSTRACT:

Background

In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of malaria, this study investigated inflammatory cytokine responses in children with malaria from areas of different transmission intensities (ranging from low to high).

Methods

Blood samples were obtained from children confirmed with malaria at community hospitals in three areas with differing transmission intensities. Cytokine levels were assessed using the Luminex^®-based magnetic bead array system, and levels were compared across sites using appropriate

SUBMITTER: Ademolue TW 

PROVIDER: S-EPMC5387356 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature