Brief Report: Plasma Concentrations of Perfluorooctane Sulfonamide and Time-to-pregnancy Among Primiparous Women.

ABSTRACT:

Background

A previous study reported a negative association between perfluorooctane sulfonamide (PFOSA) concentrations and fecundability.

Methods

We examined this association among women enrolled in the Norwegian Mother and Child Cohort Study (MoBa), in 2003-2004. This analysis was restricted to 451 primiparous women to avoid bias due to previous pregnancy. Self-reported time-to-pregnancy (TTP) and plasma were obtained around 18 weeks of gestation. Approximately half of the women had measurable PFOSA levels; missing values were multiply imputed. We used the logistic analogue of discrete-time survival analysis to examine the adjusted association between PFOSA, other perfluoroalkyl substances, and TTP.

Results

The median-measured PFOSA concentration was 0.03 ng/ml (inte

SUBMITTER: Whitworth KW 

PROVIDER: S-EPMC5387409 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature