Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.

ABSTRACT: Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of physiologically relevant processes is still unclear. Here we performed expression profiling of circRNAs during in vitro differentiation of murine and human myoblasts, and we identified conserved species regulated in myogenesis and altered in Duchenne muscular dystrophy. A high-content functional genomic screen allowed the study of their functional role in muscle differentiation. One of them, circ-ZNF609, resulted in specifically controlling myoblast proliferation. Circ-ZNF609 contains an open reading frame spanning from the start codon, in c

SUBMITTER: Legnini I 

PROVIDER: S-EPMC5387670 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature