Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation.

ABSTRACT: Atrial Fibrillation (AF) is common in the elderly and Sestrins (Sesns) have been suggested to prevent age-related pathologies. The aim of this study was to investigate the effects of Sesns in AF. Clinical data were collected and a small sample of atrial appendage and atrium was obtained from patients undergoing valve repairment. The expression of Sesn1, Sesn2, and Sesn3 was significantly higher in patients with permanent atrial fibrillation (PmAF) than that in sinus rhythm (SR), and further greater in the left atrium than the right in PmAF patients. Superoxide anion and malondialdehyde were enhanced and positively correlated to the protein expression of Sesn1/2/3. Reactive oxygen species (ROS) production and Ca²⁺ overload were significantly decreased and cell survival was enhanc

SUBMITTER: Dong Z 

PROVIDER: S-EPMC5387733 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature