Corticosteroid use and mortality risk in patients with perforated colonic diverticular disease: a population-based cohort study.

ABSTRACT:

Background

Corticosteroids are a potential risk factor for mortality in patients with perforated diverticular disease, due to blinding of disease severity, hampered wound healing or adrenal insufficiency. We examined mortality in corticosteroid users and non-users among patients with perforated diverticular disease.

Methods

A cohort study based on medical databases including all patients ≥18 years in Denmark (source population 5 289 261 inhabitants) admitted to a hospital with incident perforated diverticular disease between 2005 and 2013. 7-day, 1-month, 3-month and 1-year mortality risks in corticosteroid users and non-users were calculated using the Kaplan-Meier method, and compared with Cox proportional hazard regression adjusted for age, sex and comorbidities.

Result

SUBMITTER: Broersen LHA 

PROVIDER: S-EPMC5387955 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature