Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines.

ABSTRACT: The human genome with all its ethnic variations contributes to differences in human development, aging, disease, repair, and response to medical treatments and is an exciting area of research and clinical study. The availability of well-characterized ethnically diverse stem cell lines is limited and has not kept pace with other advances in stem cell research. Here we derived xenofree ethnically diverse-human induced pluripotent stem cell (ED-iPSC) lines from fibroblasts obtained from individuals of African American, Hispanic-Latino, Asian, and Caucasian ethnic origin and have characterized the lines under a uniform platform for comparative analysis. Derived ED-iPSC lines are low passage number and evaluated in vivo by teratoma formation and in vitro by high throughput microarray analysis o

SUBMITTER: Chang EA 

PROVIDER: S-EPMC5388175 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature