Antimicrobial photodynamic activity and cytocompatibility of Au₂₅(Capt)₁₈ clusters photoexcited by blue LED light irradiation.

ABSTRACT: Antimicrobial photodynamic therapy (aPDT) has beneficial effects in dental treatment. We applied captopril-protected gold (Au₂₅(Capt)₁₈) clusters as a novel photosensitizer for aPDT. Photoexcited Au clusters under light irradiation generated singlet oxygen (¹O₂). Accordingly, the antimicrobial and cytotoxic effects of Au₂₅(Capt)₁₈ clusters under dental blue light-emitting diode (LED) irradiation were evaluated. ¹O₂ generation of Au₂₅(Capt)₁₈ clusters under blue LED irradiation (420-460 nm) was detected by a methotrexate (MTX) probe. The antimicrobial effects of photoexcited Au clusters (0, 5, 50, and 500 μg/mL) on oral bacterial cells, such as Streptococcus mutans, Aggregatibact

SUBMITTER: Miyata S 

PROVIDER: S-EPMC5388257 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature