Testing the clinical value of multifocal electroretinography and microperimetry and the effects of intravitreal therapy with ranibizumab on macular function in the course of wet age-related macular degeneration: a 1-year prospective study.

ABSTRACT:

Purpose

To investigate the clinical value of multifocal electroretinography (mfERG) and microperimetry and the effects of intravitreal therapy with ranibizumab (Lucentis^®) on macular function in the course of neovascular age-related macular degeneration (nAMD).

Materials and methods

We conducted a prospective single-arm interventional cohort study with 20 nAMD patients older than 50 years. Examinations were scheduled monthly for 1 year during intravitreal therapy with ranibizumab. The examinations included mfERG, microperimetry, spectral domain optical coherence tomography, and best-corrected visual acuity using ETDRS score.

Results

During the 12-month observation period, a significant positive linear correlation between the logarithm of minimum angle of re

SUBMITTER: Reinsberg M 

PROVIDER: S-EPMC5388268 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature