Peroxiredoxins prevent oxidative stress during human sperm capacitation.
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ABSTRACT:
SUBMITTER: Lee D
PROVIDER: S-EPMC5388279 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Peroxiredoxins prevent oxidative stress during human sperm capacitation.
Lee Donghyun D Moawad Adel R AR Morielli Tania T Fernandez Maria C MC O'Flaherty Cristian C
Molecular human reproduction 20170201 2
<h4>Study question</h4>Do peroxiredoxins (PRDXs) control reactive oxygen species (ROS) levels during human sperm capacitation?<h4>Summary answer</h4>PRDXs are necessary to control the levels of ROS generated during capacitation allowing spermatozoa to achieve fertilizing ability.<h4>What is known already</h4>Sperm capacitation is an oxidative event that requires low and controlled amounts of ROS to trigger phosphorylation events. PRDXs are antioxidant enzymes that not only act as scavengers but ...[more]
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