Evolutionary emergence of angiogenesis in avascular tumors using a spatial public goods game.

ABSTRACT: Natural selection in cancer often results in the emergence of increasingly malignant tumor cells that display many if not all of the hallmarks of cancer. One of the most important traits acquired during cancer progression is angiogenesis. Tumor cells capable of secreting pro-angiogenic factors can be seen as cooperators where the improved oxygenation, nutrient delivery and waste disposal resulting from angiogenesis could be seen as a public good. Under this view, the relatively costly secretion of molecular signals required to orchestrate angiogenesis would be undertaken exclusively by cooperating tumor cells but the benefits of angiogenesis would be felt by neighboring tumor cells regardless of their contribution to the process. In this work we detail a mathematical model to better unders

SUBMITTER: Salimi Sartakhti J 

PROVIDER: S-EPMC5388338 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature