Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis.

ABSTRACT: MicroRNAs are important genetic regulators in both animals and plants. They have a range of functions spanning development, differentiation, growth, metabolism and disease. The advent of next-generation sequencing technologies has made it a relatively straightforward task to detect these molecules and their relative expression via sequencing. There are a large number of published studies with deposited datasets. However, there are currently few resources that capitalize on these data to better understand the features, distribution and biogenesis of miRNAs. Herein, we focus on Human and Mouse for which the majority of data are available. We reanalyse sequencing data from 461 samples into a coordinated catalog of microRNA expression. We use this to perform large-scale analyses of miRNA funct

SUBMITTER: Vitsios DM 

PROVIDER: S-EPMC5388392 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature