Systematic Review and Meta-Analysis of Patiromer and Sodium Zirconium Cyclosilicate: A New Armamentarium for the Treatment of Hyperkalemia.

ABSTRACT:

Objective

To compare and contrast the efficacy and safety of patiromer and sodium zirconium cyclosilicate (ZS-9) in the treatment of hyperkalemia.

Design

A systematic review and meta-analysis of phase II and III clinical trial data was completed.

Patients or participants

Eight studies (two phase II and four phase III trials with two subgroup analyses) were included in the qualitative analysis, and six studies (two phase II and four phase III trials) were included in the meta-analysis.

Measurements and results

Significant heterogeneity was found in the meta-analysis with an I² value ranging from 80.6-99.6%. A random-effects meta-analysis was applied for all end points. Each clinical trial stratified results by hyperkalemia severity and dosing; therefo

SUBMITTER: Meaney CJ 

PROVIDER: S-EPMC5388568 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature