β-alanine supplementation improves in-vivo fresh and fatigued skeletal muscle relaxation speed.

ABSTRACT:

Purpose

In fresh muscle, supplementation with the rate-limiting precursor of carnosine, β-alanine (BA), results in a decline in muscle half-relaxation time (HRT) potentially via alterations to calcium (Ca²⁺) handling. Accumulation of hydrogen cation (H⁺) has been shown to impact Ca²⁺ signalling during muscular contraction, carnosine has the potential to serve as a cytoplasmic regulator of Ca²⁺ and H⁺ coupling, since it binds to both ions. The present study examined the effect of BA supplementation on intrinsic in-vivo isometric knee extensor force production and muscle contractility in both fresh and fatigued human skeletal muscle assessed during voluntary and electrically evoked (nerve and superficial muscle stimulation) contr

SUBMITTER: Jones RL 

PROVIDER: S-EPMC5388709 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature