Bone Involvement in Rosai-Dorfman Disease (RDD): a Case Report and Systematic Literature Review.

ABSTRACT:

Purpose of review

Rosai-Dorfman disease (RDD) is a rare histiocytic disorder typically presenting as painless cervical lymphadenopathy. Extranodal involvement is common and may also affect bones. Here, we present a patient with typical nodal disease and multifocal bone manifestations. Further, a systematic literature review was performed to better understand the phenotype, clinical course and treatment options of such patients.

Recent findings

RDD is a nonmalignant, classically sporadic histiocytosis. Nevertheless, increasing evidence also suggests familial forms of the disease. According to our literature review, bone involvement is exceedingly rare and heterogeneous. Clinical outcome in terms of mortality seems to be favorable in most cases. Currently, therapy strategies i

SUBMITTER: Mosheimer BA 

PROVIDER: S-EPMC5388731 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature