Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar.

ABSTRACT:

Background

Human mammary tumor virus (HMTV) is 90-95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0-78%; however, the prevalence of HMTV in breast cancers from Myanmar remains unknown.

Methods

Fifty-eight breast cancer samples from Myanmar women were examined in this study. DNA was isolated from formalin-fixed paraffin-embedded specimens, and HMTV envelope sequences were detected by semi-nested PCR. The sequence of the PCR products was also confirmed.

Results

Only 1.7% (1 of 58) of the breast cancers were positive for HMTV, and the sequence of PCR products was 98.9% identical to the re

SUBMITTER: San TH 

PROVIDER: S-EPMC5389013 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature