Topical application of Jaungo in atopic dermatitis patients: study protocol for a randomized, controlled trial.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi radix and Angelica gigantis radix, and three carrier oils, and is an approved herbal ointment for xerosis cutis in Korea. In past studies, we demonstrated that Jaungo had anti-inflammatory and antiallergic activity in in vitro and in vivo AD models; however, there are few relevant randomized controlled clinical trials on Jaungo in AD.

Methods/design

A randomized, double-blind, placebo-controlled, single-center, phase IIa clinical trial was designed to investig

SUBMITTER: Yun Y 

PROVIDER: S-EPMC5389157 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature