Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors.

ABSTRACT: The regeneration of organ morphology and function following tissue loss is critical to restore normal physiology, yet few cases are documented in mammalian postnatal life. Partial hepatectomy of the adult mammalian liver activates compensatory hepatocyte hypertrophy and cell division across remaining lobes, resulting in restitution of organ mass but with permanent alteration of architecture. Here, we identify a time window in early postnatal life wherein partial amputation culminates in a localized regeneration instead of global hypertrophy and proliferation. Quantifications of liver mass, enzymatic activity, and immunohistochemistry demonstrate that damaged lobes underwent multilineage regeneration, reforming a lobe often indistinguishable from undamaged ones. Clonal analysis during regen

SUBMITTER: Tsai JM 

PROVIDER: S-EPMC5389277 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature