Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

ABSTRACT: Bacteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and in research. These metabolites are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally complex molecules from simple building blocks. The majority of BGCs in a given bacterium are not expressed under normal laboratory growth conditions, and our understanding of how they are silenced is in its infancy. Here, we have addressed this question in the Gram-negative model bacterium Burkholderia thailandensis E264 using genetic, transcriptomic, metabolomic, and chemical approaches. We report that a previously unknown, quorum-sensing-controlled LysR-type transcriptional regulator, which we name ScmR (for secondary metabolite regulator), serves as a glob

SUBMITTER: Mao D 

PROVIDER: S-EPMC5389298 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature