Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.

ABSTRACT:

Iznp-1

Multiple G-quadruplex units in the 3΄-terminal overhang of human telomeric DNA can associate and form multimeric structures. The specific targeting of such distinctive higher-order G-quadruplexes might be a promising strategy for developing selective anticancer agents with fewer side effects. However, thus far, only a few molecules were found to selectively bind to telomeric multimeric G-quadruplexes, and their effects on cancer cells were unknown. In this study, a new triaryl-substituted imidazole derivative called was synthesized and found to specifically bind to and strongly stabilize telomeric multimeric G-quadruplexes through intercalating into the pocket between the two quadruplex units. The pocket size might affect the binding behavior of . Further cellular studies in

SUBMITTER: Hu MH 

PROVIDER: S-EPMC5389520 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature