Integrative FourD omics approach profiles the target network of the carbon storage regulatory system.

ABSTRACT: Multi-target regulators represent a largely untapped area for metabolic engineering and anti-bacterial development. These regulators are complex to characterize because they often act at multiple levels, affecting proteins, transcripts and metabolites. Therefore, single omics experiments cannot profile their underlying targets and mechanisms. In this work, we used an Integrative FourD omics approach (INFO) that consists of collecting and analyzing systems data throughout multiple time points, using multiple genetic backgrounds, and multiple omics approaches (transcriptomics, proteomics and high throughput sequencing crosslinking immunoprecipitation) to evaluate simultaneous changes in gene expression after imposing an environmental stress that accentuates the regulatory features of a netwo

SUBMITTER: Sowa SW 

PROVIDER: S-EPMC5389547 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature