Arabidopsis SWI/SNF chromatin remodeling complex binds both promoters and terminators to regulate gene expression.

ABSTRACT: ATP-dependent chromatin remodeling complexes are important regulators of gene expression in Eukaryotes. In plants, SWI/SNF-type complexes have been shown critical for transcriptional control of key developmental processes, growth and stress responses. To gain insight into mechanisms underlying these roles, we performed whole genome mapping of the SWI/SNF catalytic subunit BRM in Arabidopsis thaliana, combined with transcript profiling experiments. Our data show that BRM occupies thousands of sites in Arabidopsis genome, most of which located within or close to genes. Among identified direct BRM transcriptional targets almost equal numbers were up- and downregulated upon BRM depletion, suggesting that BRM can act as both activator and repressor of gene expression. Interestingly, in addition

SUBMITTER: Archacki R 

PROVIDER: S-EPMC5389626 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature