CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

ABSTRACT:

Objective

Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs).

Methods

Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454). For controls, non-HS-Aging SNPs in APOE (rs429358/rs7412) and MAPT (rs8070723) were also analyzed against Aβ1-42 and total tau CSF analytes.

Results

The GRN risk SNP (rs5848) status correlated with variation in C

SUBMITTER: Fardo DW 

PROVIDER: S-EPMC5389672 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature