L1000CDS²: LINCS L1000 characteristic direction signatures search engine.

ABSTRACT: The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic and extrinsic benchmarking schemes, we demonstrate that processing the L1000 data with the characteristic direction (CD) method significantly improves signal to noise compared with the MODZ method currently used to compute L1000 signatures. The CD processed L1000 signatures are served through a state-of-the-art web-based search engine application called L1000CDS². The L1000CDS² search engine provides prioritization of thousands of small-molecule signatures, and their pairwise combinations, predicted to either mimic or reverse an input gene expression

SUBMITTER: Duan Q 

PROVIDER: S-EPMC5389891 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature