White Matter Tract Pathology in Pediatric Anoxic Brain Injury from Drowning.

ABSTRACT:

Background and purpose

Although drowning is a leading cause of mortality and morbidity in young children, the neuropathologic consequences have not been fully determined. The purpose of this article was to quantitatively characterize white matter microstructural abnormalities in pediatric anoxic brain injury from nonfatal drowning and investigate the correlation with motor function.

Materials and methods

Whole-brain T1-weighted and diffusion-weighted MR imaging datasets were acquired in 11 children with chronic anoxic brain injury and 11 age- and sex-matched neurotypical controls (4-12 years of age). A systematic evaluation form and scoring system were created to assess motor function. Tract-Based Spatial Statistics was used to quantify between-group alterations in the diffu

SUBMITTER: Ishaque M 

PROVIDER: S-EPMC5389897 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature